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Table 2 SNP pairs detected through analysis of pathway, network and eSNPs

From: Gene, pathway and network frameworks to identify epistatic interactions of single nucleotide polymorphisms derived from GWAS data

SNP1 chr gene P-value (snp1) SNP2 Chr gene P-value (snp2) P-value (interaction) Correlation Analysis
rs1130199 17 CDC6
RARA
1.5 × 10-5 rs4253764 22 PPARA 1.3 × 10-7 7.0 × 10-11 0.35 Pathway
rs2490429 1 ATF6
OLFML2B
2.2 × 10-7 rs41433646 12 RBM19 2.2 × 10-2 2.9 × 10-11 0.15 Subnetwork
rs4253764 22 PPARA 1.3 × 10-7 rs41433646 12 RBM19 2.2 × 10-2 9.9 × 10-10 0.33 Subnetwork
Rs12517663 5 - 5.5 × 10-1 Rs3751726 16 KLHDC4 2.9 × 10-1 9.6 × 10-10 0.09 Esnp
  1. chr stands for chromosome; Correlation: correlation coefficient between two SNPs.