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Table 5 Enriched gene ontology categories identified in the T2D risk genes.

From: Genome-wide meta-analysis of genetic susceptible genes for Type 2 Diabetes

Gene Ontology Term

Genes Involved

P Value

glucose homeostasis

16

6.16E-09

regulation of glucose transport

12

6.61E-08

regulation of insulin secretion

15

6.59E-08

glucose transport

15

3.33E-07

peptide secretion

19

2.82E-07

insulin secretion

17

3.78E-07

response to insulin stimulus

22

2.42E-06

response to peptide hormone stimulus

27

3.02E-06

cellular response to hormone stimulus

25

3.79E-06

hormone transport

20

6.62E-06

cholesterol transport

12

8.92E-06

positive regulation of glucose import

8

9.49E-06

positive regulation of fatty acid metabolic process

8

1.42E-06

cellular response to insulin stimulus

16

1.83E-05

negative regulation of macrophage derived foam cell differentiation

6

2.02E-05

positive regulation of glucose metabolic process

7

3.00E-05

regulation of lipid metabolic process

19

3.42E-05