Figure 1
From: A cross-species analysis method to analyze animal models' similarity to human's disease state
In-depth analysis of the results of the Alzheimer disease case. Alpha-estradiol and monorden are negatively connected with Alzheimer disease, while fulvestrant showed positive connection with Alzheimer. In this figure, we can see the fulvestrant-estrogen-Alzheimer pathway is more effective than the fulvestrant-Hsp90-Alzheimer pathway, so the positive connection of fulvestrant promise that estrogen pathway has more influence than the Hsp90 pathway in Alzheimer.