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Table 1 The top 10 instances obtained from gene modularization comparison method and distance comparison method in TSA case

From: A cross-species analysis method to analyze animal models' similarity to human's disease state

A. cMap ID Molecule GO counts B. cMap ID Molecule
  1050 trichostatin A 56+   448 trichostatin A
  1072 trichostatin A 55+   909 HC toxin
  448 trichostatin A 54+   1072 trichostatin A
  1014 trichostatin A 53+   1000 vorinostat
  909 HC toxin 53+   1058 vorinostat
  981 trichostatin A 52+   981 trichostatin A
  1112 trichostatin A 50+   1050 trichostatin A
  992 trichostatin A 50+   332 trichostatin A
  331 trichostatin A 50+   331 trichostatin A
  332 trichostatin A 50+   1112 trichostatin A
  1. The top 10 instances sharing the largest number of significantly affected GOMs with TSA-treated cells are listed in A and the top 10 instances resulted from distance comparison method are listed in B.
  2. For detailed parameter settings: BP is chosen as GO mode, and the P-value for cutting off insignificantly matched or reverse-matched GO modules is 0.05. 'plus' indicates the number of GO terms positively correlated; 'minus' indicates the number of GO terms negatively correlated.