A cross-species analysis method to analyze animal models' similarity to human's disease state

BMC Systems Biology

Table 1 The top 10 instances obtained from gene modularization comparison method and distance comparison method in TSA case

cMap ID	Molecule	GO counts	cMap ID	Molecule
1050	trichostatin A	56+	448	trichostatin A
1072	trichostatin A	55+	909	HC toxin
448	trichostatin A	54+	1072	trichostatin A
1014	trichostatin A	53+	1000	vorinostat
909	HC toxin	53+	1058	vorinostat
981	trichostatin A	52+	981	trichostatin A
1112	trichostatin A	50+	1050	trichostatin A
992	trichostatin A	50+	332	trichostatin A
331	trichostatin A	50+	331	trichostatin A
332	trichostatin A	50+	1112	trichostatin A

The top 10 instances sharing the largest number of significantly affected GOMs with TSA-treated cells are listed in A and the top 10 instances resulted from distance comparison method are listed in B.
For detailed parameter settings: BP is chosen as GO mode, and the P-value for cutting off insignificantly matched or reverse-matched GO modules is 0.05. 'plus' indicates the number of GO terms positively correlated; 'minus' indicates the number of GO terms negatively correlated.

ISSN: 1752-0509