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Table 3 The top 10 instances obtained from gene modularization comparison method and distance comparison method in Diabetes case

From: A cross-species analysis method to analyze animal models' similarity to human's disease state

A.

cMap ID

Molecule

GO counts

B.

cMap ID

Molecule

 

1069

15-delta prostaglandin J2

63+

 

941

rottlerin

 

887

celastrol

54+

 

839

5224221

 

893

pararosaniline

54+

 

1069

15-delta prostaglandin J2

 

1011

15-delta prostaglandin J2

53+

 

978

pyrvinium

 

839

5224221

53+

 

956

5224221

 

956

5224221

51+

 

887

celastrol

 

941

rottlerin

51+

 

893

pararosaniline

 

1140

MG-132

46+

 

1140

MG-132

 

1010

thioridazine [INN]

45+

 

1010

thioridazine [INN]

 

976

5182598

44+

 

1011

15-delta prostaglandin J2

  1. The top 10 instances sharing the largest number of significantly affected GOMs with adipocyte tissue fed by metformin are listed in A and the top 10 instances resulted from distance comparison method are listed in B.
  2. Detailed parameter settings: GO mode: BP; P-value: < 0.05.