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Table 4 The top 10 instances obtained from gene modularization comparison method and distance comparison method in Alzheimer case

From: A cross-species analysis method to analyze animal models' similarity to human's disease state

A.

cMap ID

Molecule

GO counts

B.

cMap ID

Molecule

 

415

nordihydroguaiaretic acid

25-

 

367

fulvestrant

 

966

tretinoin [INN]

22-

 

447

tretinoin

 

513

LY-294002

21-

 

3

metformin

 

367

fulvestrant [INN]

20+

 

582

butein

 

1048

alpha-estradiol

18-

 

419

chlorpromazine

 

988

estradiol [INN]

15- 1+

 

942

prazosin

 

953

monorden

16- 1+

 

970

5230742

 

502

prazosin [INN]

17+

 

448

trichostatin A

 

361

LY-294002

9- 8+

 

254

SC-58125

 

866

ikarugamycin

16+

 

460

deferoxamine

  1. The top 10 instances sharing the largest number of significantly affected GOMs with Alzheimer hippocampus cells are listed in A and the top 10 instances resulted from distance comparison method are listed in B.
  2. For detailed parameter settings: GO mode: BP; P-value: < 0.05.