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Figure 1 | BMC Systems Biology

Figure 1

From: Walking the interactome to identify human miRNA-disease associations through the functional link between miRNA targets and disease genes

Figure 1

An overview of the construction of the miRNA-disease network. Step 1: For a given miRNA and disease, we used random walk analysis using the disease genes as seeds and the miRNA targets as seeds simultaneously to obtain the ES. Step 2: Computation of p-value, used to measure the potential regulatory relationship between the miRNA and disease. Step 3: We repeated step 1 and step 2 for any disease-miRNA pair and further adopted all of the significant miRNA-disease pairs to construct a miRNA-disease network.

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BMC Systems Biology

ISSN: 1752-0509

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