SMAP performance in recalling true positives. The lowest rank for each protein structure predicted as an SMAP hit is displayed for the set of known protein targets for the five control compounds. Blue lines indicate the rank position (out of 3237) of a known target for a given compound. n = the number of screens using different protein structure templates performed for each compound. p = the p-value resulting from Mann Whitney statistical tests for individual SMAP results with respect to an individual template screen. BGC: beta-D-glucose; FCN: fosfomycin; YTZ: 4-amino-N-(1,3-thiazol-2-yl)benzenesulfonamide; TOP: trimethoprim; H3P: 2,2′-methanediylbis(3,4,6-trichlorophenol).