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Figure 4 | BMC Systems Biology

Figure 4

From: Antibacterial mechanisms identified through structural systems pharmacology

Figure 4

Predicted antibacterial mechanisms. (A) Inhibition of predicted binding targets (IspA and IspB) of 028 impacted simulated growth through decreased flux through isoprenoid synthesis pathways, leading to no growth under complete inhibition. (B) Through simulated inhibition of predicted binding targets of 2OB, critical metabolic pathways were impacted leading to decreased growth: PheA impacting amino acid synthesis, AcpP impacting lipid synthesis, EntA impacting enterochelin metabolism, and AtpB, cytochrome bo terminal oxidase, and succinate dehydrogenase all impacting oxidative phosphorylation. (C) Five compounds (F6F, PLT, 7MN, IDM, and PLS) were predicted to bind and competitively inhibit TrpB, leading to decreased tryptophan synthesis.

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