Figure 2

Computed probability distributions of oxygen-to-glucose index (OGI) at different glucose uptakes. Top left to bottom right: Uncoupling between glucose and oxygen utilization increases for increasing overall glucose uptake (i.e. enhanced glutamatergic activity). The mean OGI decreases from 5.5 to 4.5 in correspondence of an increased glucose consumption of about 15%. This behavior is in a qualitative agreement with experimental evidence, and allows for a definition of different activation states based on the uncoupling between glucose and oxygen consumption. Each OGI distribution thus identifies a subset of solutions for subsequent flux analysis.