Table 2 List of previous reports of individual miRNAs in biological processes or liver diseases of the liver and bile duct based on published literature (http://www.ncbi.nlm.nih.gov/pubmed, as of 5/3/2012)
From: Integrative genomics identifies candidate microRNAs for pathogenesis of experimental biliary atresia
Name | Relationship: liver | Relationship: bile duct |
|---|---|---|
miR-126-3p | No report | No report |
miR-30b | Inhibited TGF beta1-induced EMT, [24] downregulated after hepatectomy in rats [29] | Upregulated in LPS-induced Activated NFκB in cholangiocytes [25] |
miR-30c | Required for hepatobiliary development [10] | Required for hepatobiliary development, [10] upregulated after C.parvum infection [26] |
miR-151-3p | No report | No report |
miR-320 | Downregulated in Huh7 cells after HCV infection [21] | Downregulated in intrahepatic cholangiocarcinoma, involved in drug-triggered apoptosis [28] |
miR-676 | No report | No report |
miR-204 | No report | Downregulated in intrahepatic cholangiocarcinoma [28] |
miR-193b | Downregulated in HCC, [13] upregulated in a HCC cell line after transfection of HCV genome [20] | No report |
miR-365 | No report | No report |
miR-133a | No report | No report |
miR-200b | Downregulated in HCC, [18, 19] upregulated in NAFLD and NASH [22, 23] | Upregulated in cholangiocarcinoma cell lines [27] |
miR-133b | No report | No report |
miR-200a | Downregulated in HCC [15] and inhibited the proliferation and migration of HCC cells, [17] upregulated in NAFLD [23] | No report |
miR-195 | Downregulated in HCC, [15] suppressed growth of HCC, [14] sensitized HCC to 5-fluorouracil, [16] inhibited proliferation of HSC [30] | No report |