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Table 3 Significant topological bias of disease genes relative to non-disease genes

From: Characterization of regulatory features of housekeeping and tissue-specific regulators within tissue regulatory networks

 

In-degree

Out-degree

CC

Btwn

Brain

 

Heart

 

 

Kidney

Liver

Ovary

 

Spleen

 

 

Testis

  1. P < 0.10. cc: cluster coefficient; Btwn: betweenness, Red circle: disease miRNA; Green circle: disease TF.
  2. Red circle indicates that the relative centralities of disease miRNAs are significantly higher than those of non-disease miRNAs in the corresponding tissue. Green circle indicates that the relative centralities of disease TFs are significantly higher than those of non-disease TFs in the corresponding tissue. P < 0.10.