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Figure 6 | BMC Systems Biology

Figure 6

From: Merging concepts - coupling an agent-based model of hematopoietic stem cells with an ODE model of granulopoiesis

Figure 6

Comparison of the predictions of the hybrid model with clinical data on leukocyte dynamics in peripheral blood during chemotherapy without G-CSF. Clinical data of a) CHOP-21 and b) CHOEP-21 administration (Blue: median of patients, black: 25 and 75 percentiles) are compared with corresponding simulation results of the hybrid model (red). Simulation results fit well to clinical data in the sense that they lie in the interquartile range of data for almost all time points. Cell numbers are normalized with respect to the average WBC/leukocyte count value of healthy individuals (7000 cells/μl).

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