Comparison of the predictions of the hybrid model with clinical data on leukocyte dynamics in peripheral blood during chemotherapy with G-CSF support. Clinical data of a) CHOP-14 and b) CHOEP-14 administration (Blue: median of patients, black: 25 and 75 percentiles) are compared with corresponding simulation results of the hybrid model (red). The effect of growth factor support is reflected by the peak approximately one day after starting the G-CSF treatment at day 4 in each cycle. As for the regimens without G-CSF, simulation results fit well to clinical data. Cell numbers are normalized with respect to the average WBC/leukocyte count value of healthy individuals (7000 cells/μl).