Comparison of stem cell dynamics in ODE and hybrid model. a) Stem cell number in the ODE model (green) is heavily reduced and does not recover within one cycle. In the hybrid model, total stem cell number (red) is only reduced to ~80%. Depletion of proliferative stem cells (blue) is similar to the ODE model, but regeneration is fast. b) Effluxes from the ODE SCC (green) and the hybrid model (red) almost vanish after drug administration, but increase simultaneously around day 7.