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Table 1 List of all compartments in the ODE model and their biological equivalents

From: Merging concepts - coupling an agent-based model of hematopoietic stem cells with an ODE model of granulopoiesis

Compartment

Meaning

Biological equivalents

S

hematopoietic stem cells

hematopoietic stem cells

CG

granulopoietic progenitor cells

CFU-GM (colony forming units of granulocytes and macrophages)

PGB

proliferating granulopoietic precursor cells

myeloblasts, promyelocytes, precursor myelocytes

MGB

maturing granulopoietic precursor cells

metamyelocytes (G4), banded (G5) and segmented (G6) granulocytes

GRA

granulocytes

granulocytes in circulation

G

CG + PGB + MGB

total granulopoietic cells in bone marrow

G-CSF

G-CSF (granulocyte colony-stimulating factor)

cytokine of granulopoiesis

GM-CSF

GM-CSF (granulocyte, macrophage colony-stimulating factor)

cytokine of granulopoiesis

CX

Chemotherapy

(damaging effect of) chemotherapy