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Table 2 Parameter of the ODE model

From: Merging concepts - coupling an agent-based model of hematopoietic stem cells with an ODE model of granulopoiesis

Compartment Parameter   value
S average duration of cell cycle τ S 8 h
  amplitude of regulation for probability of self-renewal P δ 0.1
  minimal proliferative fraction a S min 0.01
  proliferative fraction at equilibrium a S nor 0.15
  proliferative fraction for intensified stimulation a S int 0.45
  maximal proliferative fraction a S max 1.0
  weight of stem cells in p ϑS 2
  weight of BM cells in p ϑG −10
  weight of stem cells in a ωS 1
  weight of bone marrow cells in a wG 0.4
CG minimal proliferative fraction a S min 0.3
  proliferative fraction at equilibrium a S nor 0.33
  proliferative fraction for intensified stimulation a S int 0.6
  maximal proliferative fraction a S max 1
  Minimal amplification A min 1
  equilibrium amplification A nor 64
  maximal amplification A max 333
  sensitivity amplification b A 0.4
  transit time T 112 h
PGB proliferative fraction a 1
  minimal amplification A min 4
  equilibrium amplification A nor 32
  maximal amplification A max 330
  sensitivity amplification b A 0.27
  transit time T 148 h
MGB-G4 number of subcompartments N G4 5
  amplification A 1
  maximal transit time (at minimal cell number) T min 60 h
  equilibrium transit time T nor 51 h
  minmal transit time T max 1 h
  sensitivity transit time b T 0.845
MGB-G5 number of subcompartments N G5 5
  amplification A 1
  transit time T min 100 h
  transit time T nor 92 h
  transit time T max 46 h
  sensitivity transit time b T 0.845
MGB-G6 number of subcompartments N G6 5
  minimal amplification A min 0.01
  equilibrium amplification A nor 0.4277
  maximal amplification A max 1
  sensitivity amplification b A 1.52
  transit time T min 140 h
  transit time T nor 22 h
  transit time T max 20 h
  sensitivity transit time b T 0.845
GRA life-time T nor 5 h
  life time prolongation by Prednison T Pred 0.66
GM-CSF maximal production rate P max 0.91 h-1
  equilibrium production rate P nor 1.0 h-1
  minimal production rate P min 310 h-1
  sensitivity production rate b P 1.7
  life time T GM-CSF 2 h
  weight of CG ω CG 1
  weight of PGB ω PGB 1
  weight of G4 ω G4 1
  weight of G5 ω G5 1
  weight of G6 ω G6 0.2
G-CSF maximal production rate P max 0.97 h-1
  equilibrium production rate P nor 1.0 h-1
  minimal production rate P min 410 h-1
  sensitivity production rate b P 0.33
  transition rate subcutaneous compartments k sc 0.75
  administered dose-equivalent d G-CSF 5.6 · 106
  duration of G-CSF infusion t inf 2 min
  transit time of unspecific degradation T G CSF ren 20 h
  transit time of GRA-specific degradation T G CSF GRA 2.8 h
  weight of G6 ω G6 0.2
  weight of GRA ω GRA 1