Merging concepts - coupling an agent-based model of hematopoietic stem cells with an ODE model of granulopoiesis

Krinner, Axel; Roeder, Ingo; Loeffler, Markus; Scholz, Markus

doi:10.1186/1752-0509-7-117

BMC Systems Biology

Table 2 Parameter of the ODE model

From: Merging concepts - coupling an agent-based model of hematopoietic stem cells with an ODE model of granulopoiesis

Compartment	Parameter		value
S	average duration of cell cycle	τ _S	8 h
	amplitude of regulation for probability of self-renewal	P _δ	0.1
	minimal proliferative fraction	$a_{S}^{min}$	0.01
	proliferative fraction at equilibrium	$a_{S}^{nor}$	0.15
	proliferative fraction for intensified stimulation	$a_{S}^{int}$	0.45
	maximal proliferative fraction	$a_{S}^{max}$	1.0
	weight of stem cells in p	ϑ_S	2
	weight of BM cells in p	ϑ_G	−10
	weight of stem cells in a	ω_S	1
	weight of bone marrow cells in a	w_G	0.4
CG	minimal proliferative fraction	$a_{S}^{\min}$	0.3
	proliferative fraction at equilibrium	$a_{S}^{nor}$	0.33
	proliferative fraction for intensified stimulation	$a_{S}^{int}$	0.6
	maximal proliferative fraction	$a_{S}^{\max}$	1
	Minimal amplification	A ^min	1
	equilibrium amplification	A ^nor	64
	maximal amplification	A ^max	333
	sensitivity amplification	b _A	0.4
	transit time	T	112 h
PGB	proliferative fraction	a	1
	minimal amplification	A ^min	4
	equilibrium amplification	A ^nor	32
	maximal amplification	A ^max	330
	sensitivity amplification	b _A	0.27
	transit time	T	148 h
MGB-G4	number of subcompartments	N _G4	5
	amplification	A	1
	maximal transit time (at minimal cell number)	T ^min	60 h
	equilibrium transit time	T ^nor	51 h
	minmal transit time	T ^max	1 h
	sensitivity transit time	b _T	0.845
MGB-G5	number of subcompartments	N _G5	5
	amplification	A	1
	transit time	T ^min	100 h
	transit time	T ^nor	92 h
	transit time	T ^max	46 h
	sensitivity transit time	b _T	0.845
MGB-G6	number of subcompartments	N _G6	5
	minimal amplification	A ^min	0.01
	equilibrium amplification	A ^nor	0.4277
	maximal amplification	A ^max	1
	sensitivity amplification	b _A	1.52
	transit time	T ^min	140 h
	transit time	T ^nor	22 h
	transit time	T ^max	20 h
	sensitivity transit time	b _T	0.845
GRA	life-time	T ^nor	5 h
	life time prolongation by Prednison	T ^Pred	0.66
GM-CSF	maximal production rate	P ^max	0.91 h^-1
	equilibrium production rate	P ^nor	1.0 h^-1
	minimal production rate	P ^min	310 h^-1
	sensitivity production rate	b _P	1.7
	life time	T ^GM-CSF	2 h
	weight of CG	ω_CG	1
	weight of PGB	ω_PGB	1
	weight of G4	ω_G4	1
	weight of G5	ω_G5	1
	weight of G6	ω_G6	0.2
G-CSF	maximal production rate	P ^max	0.97 h^-1
	equilibrium production rate	P ^nor	1.0 h^-1
	minimal production rate	P ^min	410 h^-1
	sensitivity production rate	b _P	0.33
	transition rate subcutaneous compartments	k _sc	0.75
	administered dose-equivalent	d _G-CSF	5.6 · 10⁶
	duration of G-CSF infusion	t _inf	2 min
	transit time of unspecific degradation	$T_{_{G ‒ CSF}}^{^{ren}}$	20 h
	transit time of GRA-specific degradation	$T_{_{G ‒ CSF}}^{GRA}$	2.8 h
	weight of G6	ω_G6	0.2
	weight of GRA	ω_GRA	1

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ISSN: 1752-0509

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