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Table 4 Parameter of the stem cell compartment in the hybrid model

From: Merging concepts - coupling an agent-based model of hematopoietic stem cells with an ODE model of granulopoiesis

Time step

Δt

1 h

Differentiation coefficient

d

1.10252

Regeneration coefficient

r

1.05001

Threshold to differentiated cells

a min

0.002

Maximum stem cell affinity

a max

1.0

Cycle time

Ï„c

49 h

S/G2/M-phase

Ï„S

17 h

Transition Characteristics

Ω → Α

fΑ(0)

0.5

fΑ( ÑΑ /2)

0.45

fΑ( ÑΑ )

0.05

fΑ(∞)

0.0

Ñ Α

105

Α → Ω

fΩ(0)

0.5

fΩ( ÑΩ /2)

0.3

fΩ( ÑΩ)

0.1

fΩ(∞)

0.0

Ñ Ω

105