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Figure 3 | BMC Systems Biology

Figure 3

From: Knowledge-based compact disease models identify new molecular players contributing to early-stage Alzheimer’s disease

Figure 3

Biological network-based model of interactions between the most essential Alzheimer’s disease-related genes representing the sub-network 1 of Table 2. Green figures indicate down-regulation, red figures indicate upregulation, grey figures mean unchanged expression levels. Rectangular figures indicate receptors, rombi –peptidases, triangles – kinases/phosphatases, circles –other; solid connecting line – binding only, solid connecting arrow – acts upon, dotted lines indicate indirect functional relationships (such as co-regulation of expression of both genes in cell lines).

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