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Table 2 Top 10 miRNAs and TFs with highest out-degree in lung cancer synergistic regulatory network

From: Functional analysis of microRNA and transcription factor synergistic regulatory network based on identifying regulatory motifs in non-small cell lung cancer

Top Regulator Out- degree Supported bya
1 hsa-miR-590-3p 320 -
2 hsa-miR-548c-3p 302 -
3 hsa-miR-570 243 -
4 hsa-miR-340 242 -
5 hsa-miR-495 218 -
6 hsa-miR-106ab 207 PMID: 19209007
7 hsa-miR-106bb 202 -
8 hsa-miR-20ab 201 PMID: 16266980
9 hsa-miR-20bb 200 -
10 hsa-miR-944 200 -
1 MYC 116 PMID: 11720740
2 TP53 95 PMID: 12619108
3 E2F1 73 PMID: 22803943
4 TFAP2A 64 PMID: 22143938
5 SP1 61 PMID: 22158040
6 JUN 59 -
7 E2F4 50 PMID: 19473719
8 HIF1A 48 PMID: 22115707
9 NFKB1 48 -
10 STAT1 44 PMID: 17348819
  1. aSupported by: published articles in which the TF or miRNA was experimentally verified as being related to lung cancer development and progression.
  2. bbelongs to the miR-17 family.