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Table 6 Biology process terms regulated by the miRNA-TF synergistic regulatory network

From: Functional analysis of microRNA and transcription factor synergistic regulatory network based on identifying regulatory motifs in non-small cell lung cancer

GO term Annotation Ranka In motifsb
GO:0042981 Regulation of apoptosis 1 10
GO:0032268 Regulation of cellular protein metabolic process 2 10
GO:0007167 Enzyme linked receptor protein signaling pathway 3 9/I
GO:0031399 Regulation of protein modification process 4 10
GO:0042325 Regulation of phosphorylation 5 10
GO:0019220 Regulation of phosphate metabolic process 6 10
GO:0051329 Interface of mitotic cell cycle 7 10
GO:0000082 G1/S transition of mitotic cell cycle 8 9/IV
GO:0001932 Regulation of protein phosphorylation 9 10
GO:0007169 Transmembrane receptor protein tyrosine kinase signaling pathway 10 9/I
GO:0071156 Regulation of cell cycle arrest 11 9/IV
GO:0045859 Regulation of protein kinase activity 12 10
GO:0000075 Cell cycle checkpoint 13 9/IV
GO:0006259 DNA metabolic process 14 10
GO:0006281 DNA repair 15 9/IV
GO:0043549 Regulation of kinase activity 16 10
GO:2000045 Regulation of G1/S transition of mitotic cell cycle 17 9/IV
GO:0000084 S phase of mitotic cell cycle 18 9/IV
GO:0051320 S phase 19 9/IV
GO:0007093 Mitotic cell cycle checkpoint 20 9/IV
GO:0031575 Mitotic cell cycle G1/S transition checkpoint 21 8/III, IV
GO:0071779 G1/S transition checkpoint 22 8/III, IV
GO:0006468 Protein phosphorylation 23 9/I
GO:0043066 Negative regulation of apoptosis 24 9/I
GO:0043069 Negative regulation of programmed cell death 25 9/I
GO:0031328 Positive regulation of cellular biosynthetic process 26 9/I
GO:0071900 Regulation of protein serine/threonine kinase activity 27 9/I
GO:0009968 Negative regulation of signal transduction 28 9/I
GO:0048011 Nerve growth factor receptor signaling pathway 29 9/I
GO:0046777 Protein autophosphorylation 30 7/I, II, V
GO:0006355 Regulation of transcription, DNA-dependent 31 9/I
GO:2001141 Regulation of RNA biosynthetic process 32 9/I
GO:0009967 Positive regulation of signal transduction 33 8/I, V
GO:0006357 Regulation of transcription from RNA polymerase II promoter 34 9/I
GO:0043065 Positive regulation of apoptosis 35 9/I
GO:0045893 Positive regulation of transcription, DNA-dependent 36 8/I,III
  1. aRank: is the rank number calculated using the formula (2.7.1) based on the number of occurrences of the GO terms among all the assigned terms.
  2. bIn motifs: is how many motif types (subnetworks) were assigned the corresponding GO term. The roman number(s) following the slash indicate the subnetwork(s) in which the corresponding GO term was not found.