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Table 7 Pathways regulated by miRNA-TF synergistic regulatory network

From: Functional analysis of microRNA and transcription factor synergistic regulatory network based on identifying regulatory motifs in non-small cell lung cancer

Pathway name

Ranka

In motifsb

p53 pathway

1

8

Direct p53 effectors

2

8

Regulation of Telomerase

3

7

Hypoxia and oxygen homeostasis regulation of HIF-1-alpha

4

8

Arf6 signaling events

5

8

Cell Cycle, Mitotic

6

7

S Phase

7

6

Synthesis of DNA

8

7

DNA Replication

9

6

Regulation of DNA replication

13

5

G1/S Transition

10

6

IGF1 pathway

11

6

Orc1 removal from chromatin

12

5

Switching of origins to a post-reflective state

14

5

Removal of licensing factors from origins

15

5

Signaling events regulated by Ret tyrosine kinase

16

4

EphrinA-EPHA pathway

17

3

E-cadherin signaling events

18

7

FOXA transcription factor networks

19

6

E2F transcription factor network

20

7

Neurotrophic factor-mediated Trk receptor signaling

21

9

Canonical Wnt signaling pathway

22

7

  1. aRank: is the rank number calculated using the formula (2.7.1) based on the number of occurrences of the pathways among all the assigned pathways.
  2. bIn motifs: is how many motif subnetworks were assigned the corresponding pathways.