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Figure 2 | BMC Systems Biology

Figure 2

From: Kinetic modelling of phospholipid synthesis in Plasmodium knowlesi unravels crucial steps and relative importance of multiple pathways

Figure 2

Schematic overview of P. knowlesi reactions in structural phospholipid biosynthesis as demonstrated by experimental work. Solid lines correspond to metabolite transport or biochemical reactions with an identified enzyme whereas dotted line correspond to reaction identified with unidentified enzyme. Squares represent the phospholipid end products. Hexagons represent the enzymes. R1 to R17 denote the reaction rates/fluxes. List of species : SerE = exogenous serine, Ser = intracellular serine, PS = phosphatidylserine, EtnE = exogenous ethanolamine, Etn = intracellullar ethanolamine, PEtn = phosphoethanolamine, PE = phosphatidylethanolamine, ChoE = exogenous choline, Cho = intracellular choline, PCho = phosphocholine, PC = phosphatidylcholine,DAG = diacylglycerol, SD = serine decarboxylase, PSSbe = phosphatidylserine synthase I, PMT = phosphoethanolamine-N-methyltransferase, PEMT = phosphophatidylethanolamine-N-methyltransferase, CCT = cholinephosphate cytidylyl transferase, ECT = ethanolaminephosphate cytidylyl transferase, CEPT = choline/ethanolamine phosphotransferase, CK = choline kinase, EK = ethanolamine kinase, NPP = New permeation pathway, OCT = Organic cationic transporter, ? = putative genes found.

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