Stationary reaction fluxes. Four modified versions of the network of conformational substates with the internal and external transitions between them pictured in Figure 3. The considered schematic diagrams enable calculation, by using the Hill or Monte Carlo methods, the steady-state fluxes for the input/output reactions in the forward (a)/(c) and the backward (b)/(d) directions. The successive external transitions have been redirected to the additional node connected to the network and labeled here by the symbol, ∗. For instance, the forward reaction flux (a) is equivalent to the reciprocal MFPT from the gate 1′ to the node ∗, through the intermediate gate 1′′.