Figure 5

Integration scheme used in this study. Different levels of abstractions used in this study to obtain essential genes are shown. Different methods are highlighted with different colours as shown in the top panel, phylogenetic analysis (blue), transcriptome profiling (yellow), protein-protein interaction (green) and metabolic analysis (red). All the methods are integrated using set theory to obtain a list of high confidence essential genes as shown in the Venn diagram. The final set of essential genes is further analysed to probe into residue level conservation and binding site analysis (lower panel).