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Figure 7 | BMC Systems Biology

Figure 7

From: Carbon catabolite repression correlates with the maintenance of near invariant molecular crowding in proliferating E. coli cells

Figure 7

Model of metabolic adaptations in rapidly proliferating cells. Slowly growing bacterial cells use oxidative phosphorylation (OxPhos) and CCR is absent. Upon increased growth (transition A), prokaryotes expand cell volume to accommodate the faster biomass accumulation rate. At faster growth rate (transition B) prokaryotes also turn on glycolysis and activate CCR in order to maintain cytoplasmic MC within a narrow, optimal range (blue shaded area). In the absence of such accommodation mechanisms cytoplasmic MC would be sub-optimal leading to a reduced growth rate (transition C).

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