Figure 1From: Detecting cellular reprogramming determinants by differential stability analysis of gene regulatory networksDescription of transitions between cellular phenotypes using transcriptional landscapes and networks. a) Cell transcriptional program landscape representing two attractors and the epigenetic barrier between them. This conceptual figure represents a cell stabilized in an initial cellular phenotype and how a hypothetical perturbation can destabilize the cellular program and make cell exceed the barrier and fell down in a final cellular phenotype. This cellular reprogramming is represented as a blue arrow from the initial to the final attractor. b) Cellular reprogramming as transitions between network states. Differentially expressed positive circuits (DEPCs) are perturbed to induce the transition from Attractor 1 to Attractor 2 passing by a transient state. This transient state can be considered as a “short” term changing expression pattern until the system reaches an attractor. Regular arrows represent activation and T-arrows represent inhibitions. Blue and red nodes represent inactive and active genes respectively in attractors. Violet nodes represent transient states.Back to article page