From: Systems biology approach to stage-wise characterization of epigenetic genes in lung adenocarcinoma
Stage/DNA methylated genes identified as TFs | Significance |
---|---|
Common across Stages (Table 2 ) | |
FOXG1 | Cell adhesion, Growth and invasion of lung cancer [68] and is prognostic marker in bladder cancer [69] |
HAND2 | Identified in early stage in squamous cell carcinoma but not in adenocarcinoma [70] |
HOXB4 | Overexpression identified in ovarian cancer though HOX genes are reported in lung cancer [71] |
PHOX2A | Abnormal methylation in NSCLC [72] |
Unique TFs in Stage I (total 6) | |
HLA-G | Potential biomarker in lung cancer [73] |
BCL11B | A new therapeutic for T-cell malignancies but direct correlation with lung cancer not available [74, 75] |
UTF1 | Not yet correlated in lung cancer but a prognostic in cervical cancer [76] |
Unique TFs in Stage II (total 6) | |
EMX2 | Is associated with WNT signaling pathway and its down-regulation is associated with methylation of promoter region in lung cancer suggesting it as novel suppressor gene for human lung cancer [77] |
NKX6-2 | Identified as methylated in lung cancer [40] and identified as target in Pancreatic cancer [78] |
OLIG2 | Identified in lung cancer but not study as target [79] |
ZNF577 | Identified as methylated in various cancers like breast and oropharyngeal squamous cell carcinoma, very recently in lung cancer [80]. Not much is reported with respect to its prognostic value. |
Unique TFs in Stage III (total 13) | |
EPO | Is the key regulator in the production of RBC, methylation of the promoter section of EPO is identified in many cancers including lung, breast liver etc. [81] though its prognostic value efficiency is not reported. |
GERM1 | Hypermethylation of GREM1 is identified for prognostic significance in renal cell carcinoma [82], so far not in lung cancer. |
IRX1 | Methylation is identified in lung cancer [83] but needs to be studied for prognostic markers. |