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Table 8 Analysis of hub genes in the DNA methylated subnetworks of size 4

From: Systems biology approach to stage-wise characterization of epigenetic genes in lung adenocarcinoma

Stage Subnetwork Connectivity profile of the hub node across pathways
Cancer Lung cancer Signaling Metabolic + others
I (i) PHOX2A*:HAND2*:PPP2R5D:UBC 23 13 71 288
(ii) HLA-G*:COPB1:TRIM37:UBC
(iii) LY96*:TLR4:SIGIRR:UBC
  (iv) HLA-G*:COPB1:UBC:CUL1 21 14 35 114
(v) FOXG1*:FOXH1:SMAD3:CUL1
  (vi) HLA-G*:COPB1:UBC:SKP2 19 10 17 38
II (i) PHOX2A*:c-JUN:SUMO3:UBC 23 14 74 254
(ii) TAL1*:HDAC1:IRF5:UBC
  (iii) PRKCB*:HIST1H3I:CUL4A:CUL1 20 14 74 253
III (i) PHOX2A*:c-JUN:SUMO3:UBC 22 10 64 235
(ii) PHOX2A*:HAND2*:PPP2R5D:UBC
  (iii) PRKCB*:HIST1H3I:CUL4A:CUL1 20 13 35 102
  1. * : identified in Table2.