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Table 8 Analysis of hub genes in the DNA methylated subnetworks of size 4

From: Systems biology approach to stage-wise characterization of epigenetic genes in lung adenocarcinoma

Stage

Subnetwork

Connectivity profile of the hub node across pathways

Cancer

Lung cancer

Signaling

Metabolic + others

I

(i) PHOX2A*:HAND2*:PPP2R5D:UBC

23

13

71

288

(ii) HLA-G*:COPB1:TRIM37:UBC

(iii) LY96*:TLR4:SIGIRR:UBC

 

(iv) HLA-G*:COPB1:UBC:CUL1

21

14

35

114

(v) FOXG1*:FOXH1:SMAD3:CUL1

 

(vi) HLA-G*:COPB1:UBC:SKP2

19

10

17

38

II

(i) PHOX2A*:c-JUN:SUMO3:UBC

23

14

74

254

(ii) TAL1*:HDAC1:IRF5:UBC

 

(iii) PRKCB*:HIST1H3I:CUL4A:CUL1

20

14

74

253

III

(i) PHOX2A*:c-JUN:SUMO3:UBC

22

10

64

235

(ii) PHOX2A*:HAND2*:PPP2R5D:UBC

 

(iii) PRKCB*:HIST1H3I:CUL4A:CUL1

20

13

35

102

  1. * : identified in Table2.