From: Systems biology approach to stage-wise characterization of epigenetic genes in lung adenocarcinoma
Stage | Subnetwork | Connectivity profile of the hub node across pathways | |||
---|---|---|---|---|---|
Cancer | Lung cancer | Signaling | Metabolic + others | ||
I | (i) PHOX2A*:HAND2*:PPP2R5D:UBC | 23 | 13 | 71 | 288 |
(ii) HLA-G*:COPB1:TRIM37:UBC | |||||
(iii) LY96*:TLR4:SIGIRR:UBC | |||||
 | (iv) HLA-G*:COPB1:UBC:CUL1 | 21 | 14 | 35 | 114 |
(v) FOXG1*:FOXH1:SMAD3:CUL1 | |||||
 | (vi) HLA-G*:COPB1:UBC:SKP2 | 19 | 10 | 17 | 38 |
II | (i) PHOX2A*:c-JUN:SUMO3:UBC | 23 | 14 | 74 | 254 |
(ii) TAL1*:HDAC1:IRF5:UBC | |||||
 | (iii) PRKCB*:HIST1H3I:CUL4A:CUL1 | 20 | 14 | 74 | 253 |
III | (i) PHOX2A*:c-JUN:SUMO3:UBC | 22 | 10 | 64 | 235 |
(ii) PHOX2A*:HAND2*:PPP2R5D:UBC | |||||
 | (iii) PRKCB*:HIST1H3I:CUL4A:CUL1 | 20 | 13 | 35 | 102 |