Table 9 Enrichment analysis of the top scored subnetworks
From: Systems biology approach to stage-wise characterization of epigenetic genes in lung adenocarcinoma
Stage | Biological Process | p-value | Genes in subnetworks |
|---|---|---|---|
Common across all Stages | Activation of MAPKK activity | 1.12E-03 | PHOX2A*, HAND2*, PPP2R5D, UBC, KRAS, PIK3CA, PIK3R3, RAF1, BRAF, RAP1A |
I & II | Co-SMAD binding | 1.2E-05 | FOXG1*, FOXH1, SMAD2, SMAD1, MED15, UBC, KRAS, PIK3CA, PIK3R3, RAF1, BRAF, RAP1A |
II & III | Nerve growth factor receptor signaling pathways | 2.21E-04 | HOXD4*, INPP5B, SLC6A2, STX1A, VAMP1, UBC, KRAS, PIK3CA, PIK3R3, RAF1, BRAF, RAPIA |
I & III | Positive regulation of peptidyl-serine phosphorylation | 1.42E-03 | NPY*, NPY1R, LSM7, NR1H2, RMI1, UBC, KRAS, PIK3CA, PIK3R3, RAF1, BRAF |
I | Transmembrane receptor protein tyrosine kinase signaling pathway | 1.87E-03 | HLA-G*, COPB1, UBC, KRAS, PIK3CA, PIK3R3, RAF1, BRAF, RAP1A |
II | DNA helicase complex | 6.8E-05 | SERPINB5*, UCHL5, ACTR8, ACTR5, UBC, KRAS, PIK3CA, PIK3R3, RAF1, BRAF |
III | Nerve growth factor receptor signaling pathway | 5.5E-04 | HOXB4*, CREBBP, KLF13, UBC, KRAS, PIK3CA, PIK3R3, RAF1, BRAF, RAP1A |