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Table 2 BioPAX instances and ontology terms corresponding to KGML relation subtypes

From: Precise generation of systems biology models from KEGG pathways

Relation subtype

BioPAX element

SBO term

MI term

GO term

activation

conversion, control

170 (stimulation)

none

none

inhibition

conversion, control

169 (inhibition)

none

none

expression

TemplateReaction, -Regulation

170 (stimulation)

none

10467

repression

TemplateReaction, -Regulation

169 (inhibition)

none

none

indirect effect

conversion

344 (molecular interaction)

none

none

state change

conversion

168 (control)

none

none

binding/association

ComplexAssembly

177 (non-covalent binding)

914

5488

dissociation

ComplexAssembly

180 (dissociation)

none

none

missing interaction

MolecularInteraction

396 (uncertain process)

none

none

phosphorylation

conversion, control

216 (phosphorylation)

217

16310

dephosphorylation

conversion, control

330 (dephosphorylation)

203

16311

glycosylation

conversion, control

217 (glycosylation)

559

70085

ubiquitination

conversion, control

224 (ubiquitination)

220

16567

methylation

conversion, control

214 (methylation)

213

32259

  1. This table shows how relations are handled during conversion to BioPAX or SBML. The conversion depends on the subtype of each relation. For each subtype, the corresponding BioPAX element, as well as terms from different ontologies are specified. When converting to BioPAX, all terms are annotated as an instance of InteractionVocabulary, whereas an SBML transition has a field for the SBO term and other terms are added as controlled vocabularies on the transition. Please note that some BioPAX elements are subject to certain conditions and others need to be replaced by more generic classes in BioPAX Level 2, due to differences in both releases. Please see the KEGG to BioPAX section for more details.