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Figure 1 | BMC Systems Biology

Figure 1

From: A mathematical model of the unfolded protein stress response reveals the decision mechanism for recovery, adaptation and apoptosis

Figure 1

The wiring diagram of the UPR model. The complete UPR model comprises 27 species interconnected with 62 biochemical reaction channels in four compartments, ER, nucleus, Golgi body, and cytoplasm. The model utilises a total of 82 parameters. For sake of simplicity, some of the details and the apoptotic BAX/BAK/BH3 pathway have been omitted from the figure. Please refer to Additional file 1: Text 1 for the complete set of equations and parameters.

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