Figure 6
The ATF6 branch of the adaptive response module. The figure shows the three compartments involved in the mechanism of ATF6 activation. When BiP dissociates, the receptor is transported to the Golgi body as a monomer, and then it is cleaved by serine proteases. The cleaved domain, ATF6p50, acts as a transcription factor regulating the XBP1 branch and the translation attenuation module. It also activates WFS1, which controls the degradation of the receptor from the ER membrane.