Figure 9

Bifurcation diagrams showing the three activity states proposed by the translation attenuation module. Solid dark curves indicate stable stationary points as they evolve through the three states in response to increasing levels of active PERK (PERKA). Dashed dark curves indicate unstable stationary points, and the solid grey curves indicate the minimum and maximum values of CHOP (a) and eIF2α (b) oscillations. HB stands for Hopf bifurcation where a limit cycle transcends into dumped oscillations.