Figure 3

Dynamics of the model without RNA-part. Model without RNA-part. (Upper left panel) Slip bond model with Rac-IC. Note the very short time scale of below one minute for focal complex assembly, the high level of focal complexes and the very low (close to zero) level of focal adhesions. (Upper right panel) Effect of Rho-IC. Now the time scale is about 30 minutes. The result is a high steady state level of focal adhesions and a much lower level of focal complexes. (Lower left panel) Dynamics of the catch bond model with Rac-IC. The result is similar to the slip bond case due to the low level of force. (Lower right panel) Dynamics of the catch bond model with Rho-IC. The time scale remains the same as in the slip bond model, however, the steady state level of focal adhesions is noticeably higher as the focal adhesions are more stable in the catch bond case. Parameter set PS1 was used for these plots.