Figure 8

Knockdown of Rho and of an additional regulating species. (A) Effect of Rho knockdown. While the steady state amount of focal adhesions decreases, the amount of focal complexes increases due to the increased amount of Rac. The slip bond model with parameter set PS2 and Rho-IC was used for this plot. (B) Effect of a knockdown of an additional species Z acting on the degradation of C (see inset). Degradation of Z leads to an increased amount of C and a subsequent increase in the concentrations of both focal complexes and focal adhesions. The slip bond model with parameter set PS3 and Rho-IC was used for this plot.