Gene expression simulation results. Gene expression data were simulated using the simulateDatExpr5Modules function under the WGCNA package in R. An adjacency matrix was then calculated from the Pearson correlation coefficients for the expression levels of each pair of genes. These plots reveal the relationship between the intramodular propensity and the true module membership, kME in (Eq. 3), first in all the clusters combined (top left) and then in each of the five clusters individually. Note the strong correlation and significant p-value in all cases.