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Table 4 Disease network top 20 significant connections PPP model

From: Cluster and propensity based approximation of a network

  Disease 1 Disease 2 C1 C2 - Log10(P)
1 Muscular dystrophy-dystroglycanopathy (limb-girdle) Muscular dystrophy-dystroglycanopathy (congenital) 2 2 13.31
2 Zellweger syndrome Adrenoleukodystrophy 14 14 12.06
3 Leber congenital amaurosis Retinitis pigmentosa 6 6 10.12
4 Neuropathy Charcot-Marie-Tooth disease 12 12 8.99
5 Blood group Malaria 13 13 8.76
6 Ullrich congenital muscular dystrophy Bethlem myopathy 14 14 8.57
7 Iminoglycinuria Hyperglycinuria 14 14 8.57
8 Usher syndrome Deafness 8 8 8.48
9 Hemolytic uremic syndrome Macular degeneration 10 10 8.24
10 Bronchiectasis with or without elevated sweat chloride Pseudohypoal-dosteronism 11 11 7.75
11 Refsum disease Zellweger syndrome 14 14 7.14
12 Meckel syndrome Joubert syndrome 6 6 7.08
13 Omenn syndrome Severe combined immunodeficiency 14 14 6.99
14 Left ventricular noncompaction Cardiomyopathy 12 12 6.97
15 Mitochondrial complex I deficiency Leigh syndrome 2 2 6.85
16 Alport syndrome Hematuria 14 14 6.70
17 Colorblindness Blue cone monochromacy 14 14 6.70
18 Atrial fibrillation Long QT syndrome 2 2 6.64
19 Cone-rod dystrophy Retinitis pigmentosa 6 6 6.56
20 Microphthalmia with coloboma Microphthalmia 6 6 6.46