Novel semantic similarity measure improves an integrative approach to predicting gene functional associations

BMC Systems Biology

Table 4 Confirmation of GAP’s novel predictions

Interactor	Interaction	Interaction	Confirmed by:	Journal	Year	Experimental
set	pair	type	Pubmed ID			method
Random	ACTN4 and SYNPO	Complex	12042308	J Biol Chem	2002	Co-IP, Pull down
	FGF2 and VEGFA	Regulation	18948122	Microvasc Res	2009	N/A
	NPHS1 and ACTN4	Direct	16837631	J Am Soc Nephrol	2006	Co-IP
	VHL and SDHB	Association	19208735	Endocr Relat Cancer	2009	N/A
	BRMS1 and SAP130	Complex	16914451	Nucleic Acids Res	2006	TAP Tag
Metastasis	CD82 and AMFR	Direct	18037895	Nat Med	2007	Co-IP
Suppressor	KISS1 and KAL1	Association	22335740	N Engl J Med	2012	N/A
	KISS1 and MED23	Regulation	16964286	Oncogene	2007	ChIP

This Table summarizes a list of confirmed interactions, types of the interactions, corresponding PubMed IDs, and the experimental methods used.

ISSN: 1752-0509