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Figure 5 | BMC Systems Biology

Figure 5

From: The last generation of bacterial growth in limiting nutrient

Figure 5

By increasing the levels of assimilating proteins bacteria reach their final OD faster. A schematic representation for a mechanism for rapid growth in the last generation. A pulse of metabolic proteins allows the cell to compensate for a sharp decline in substrate. This allows continued exponential growth at about the same speed as maximal exponential growth rate. Growth ends abruptly when substrate goes below the Monod constant. If the pulse of metabolic enzymes is prevented (eg. by mutating the regulators), a gradual stop of growth is obtained. In a hypothetical competition between the wild-type and mutant strain, the wild-type would deplete resources faster and outgrow the mutant in the last generation. Over repeats of this competition, the wild-type strain would be selected. This is a basis for the potential selective advantage of the regulatory strategy found in the present study.

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