Skip to main content


Figure 5 | BMC Systems Biology

Figure 5

From: Probabilistic strain optimization under constraint uncertainty

Figure 5

Monte Carlo sampling based optimization (MCOpt) of antibody production using the CHO cell model. Each panel shows a MCOpt calculated distribution of target flux values, with the rows and columns corresponding to different caps on the number of interventions (L) and different intervention sets, respectively. For L = 1 or 2, MCOpt identified only one intervention set. The x-axis represents the maximum antibody production rate in units of nmol/106cells/day. The dashed lines denote the 5th and 95th percentile values. The selection frequency of an intervention set as a fraction of the total pool of MCOpt solutions for a given L is shown as a percentile value at the top of each panel.

Back to article page