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Figure 8 | BMC Systems Biology

Figure 8

From: Probabilistic strain optimization under constraint uncertainty

Figure 8

Monte Carlo sampling based flux balance analysis (FBA) simulations of the intervention sets identified by CCOpt and DetOpt for tripalmitoylglycerol production using the adipocyte model. Each panel shows a Monte Carlo distribution of FBA optimized target flux values, with the rows and columns corresponding to different caps on the number of interventions (L) and different optimization methods/settings, respectively. Results are shown only for L = 2 and 3, as setting L = 1 failed to produce any solutions (empty sets in Figure 7). The x-axis represents the maximum production rate in units of mmol/g-DNA/2 days. The y-axis represents the sampled frequency of an FBA solution. The dashed lines denote the 5th and 95th percentile values. The solid lines indicate the maximum production rates obtained using CCOpt or DetOpt.

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