TY - JOUR AU - Liebal, Ulf W. AU - Millat, Thomas AU - Marles-Wright, Jon AU - Lewis, Richard J. AU - Wolkenhauer, Olaf PY - 2013 DA - 2013/01/15 TI - Simulations of stressosome activation emphasize allosteric interactions between RsbR and RsbT JO - BMC Systems Biology SP - 3 VL - 7 IS - 1 AB - The stressosome is a bacterial signalling complex that responds to environmental changes by initiating a protein partner switching cascade, which leads to the release of the alternative sigma factor, σB. Stress perception increases the phosphorylation of the stressosome sensor protein, RsbR, and the scaffold protein, RsbS, by the protein kinase, RsbT. Subsequent dissociation of RsbT from the stressosome activates the σB cascade. However, the sequence of physical events that occur in the stressosome during signal transduction is insufficiently understood. SN - 1752-0509 UR - https://doi.org/10.1186/1752-0509-7-3 DO - 10.1186/1752-0509-7-3 ID - Liebal2013 ER -