Figure 4

Correlation of the CLGF circuit with clinical variables. (A) PANSS negative symptom score was correlated with the number of CLGF circuits in the functional feedback networks of schizophrenia (R = -0.5376, p = 0.039) whereas PANSS positive, negative, general, and total symptom scores did not show significant correlations. (B) Schematic diagram summarizing this study. Relative to healthy controls, schizophrenia patients exhibit reduced interaction between interregional and intraregional connections, leading to impairment of CLGF circuit. Deficits in the coupled feedback circuit result in abnormal oscillations such as reduced gamma power and increased beta synchronization in the schizophrenia patients group. Reduced beta-gamma power switching might also be attributed to the impairment of CLGF circuit. Schizophrenia patients exhibited that PANSS negative symptom score is inversely proportional to the number of CLGF circuits. This suggests that negative symptoms of schizophrenia is also involved in the disconnectivity of coupled cortical connections.