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Table 5 The list of proteins with both high BC and large degree and their functions

From: Construction and analysis of the protein-protein interaction network related to essential hypertension

Symbol

Function description

NOS3

Produces nitric oxide which is implicated in vascular smooth muscle relaxation.

CYP2E1

An effective producer of reactive oxygen species.

KNG1

Precursor of vasoactive kinins.

NPY

A peptide with direct and potential effects on vasoconstriction.

HIF1A

Functions as a master transcriptional regulator of the adaptive response to hypoxia.

POMC

Controls energy homeostasis.

REN

Generates angiotensin I from angiotensinogen in the plasma.

TNF

A proinflammatory cytokine which induce endothelial dysfunction.

PTH

Elevates calcium level by dissolving the salts in bone and preventing their renal excretion.

SRC

Involves in cell maintenance and communication.

AKT1

Phosphorylates NOS3.

PTGER3

Receptor for prostaglandin E2.

INS

Decreases blood glucose concentration.