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Table 11 Metabolites with the largest essential carbon fluxes

From: A metabolite-centric view on flux distributions in genome-scale metabolic models

Metabolite C atoms Minimum flux Minimum C flux
glucose 6-phosphate 6 11 66
glyceraldehyde 3-phosphate 3 17.75 53.26
3-phospho-D-glycerate 3 17.75 53.24
1,3-bisphospho-D-glycerate 3 17.75 53.24
2-phospho-D-glycerate 3 16.3 48.89
PEP 3 16.3 48.89
L-glutamate 5 8.46 42.28
2-oxoglutarate 5 8.12 40.62
pyruvate 3 13.3 39.9
fructose 6-phosphate 6 6.59 39.55
6-phospho-D-gluconate 6 5.62 33.7
6-phospho-D-glucono-1,5-lactone 6 5.62 33.7
D-ribulose 5-phosphate 5 5.62 28.08
dihydroxyacetone phosphate 3 8.23 24.68
CO2 1 23.5 23.5
acetyl-CoA 2* 10.82 21.64
oxaloacetate 4 4.3 17.21
D-xylulose 5-phosphate 5 3.09 15.47
acetate 2 6.4 12.8
D-ribose 5-phosphate 5 2.5 12.5
  1. Fluxes are in mmol gDW−1 h−1. *discounting CoA moiety.