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Table 5 NADPH balance

From: A metabolite-centric view on flux distributions in genome-scale metabolic models

Producing fluxes
Reaction/Enzyme Pathway/Product Ratio
glucose 6-phosphate dehydrogenase pentose phosphate pathway 40.35%
phosphogluconate dehydrogenase pentose phosphate pathway 40.35%
isocitrate dehydrogenase TCA cycle 13.40%
methylenetetrahydrofolate dehydrogenase purines 5.89%
Consuming fluxes
Reaction/Enzyme Pathway/Product Ratio
glutamate dehydrogenase Glu 51.65%
3-oxoacyl-[acyl-carrier-protein] reductase (11 reactions) fatty acids 13.41%
ketol-acid reductoisomerase (2 reactions) Val, Leu, Ile, coenzyme A 6.95%
aspartate semialdehyde dehydrogenase Thr, Met, Lys, peptidoglycans 6.43%
sulfite reductase sulfur metabolism 4.57%
homoserine dehydrogenase Thr, Met 4.21%
shikimate dehydrogenase shikimate pathway 2.28%
dihydrodipicolinate reductase Lys, peptidoglycans 2.22%
thioredoxin reductase conversions to other redox carriers 2.14%
N-acetyl-γ-glutamyl-phosphate reductase Arg, polyamines 2.01%
glutamate 5-semialdehyde dehydrogenase Pro 1.32%
pyrroline 5-carboxylate reductase Pro 1.32%
glycerol 3-phosphate dehydrogenase phospholipids 1.03%
UDP-N-acetylenolpyruvoylglucosamine reductase peptidoglycans 0.17%
dihydrofolate reductase folate metabolism 0.16%
dTDP-4-dehydrorhamnose reductase lipopolysaccharides 0.05%
  1. Total flux: 13.9 mmol gDW−1 h−1. Ratios below 0.05% not shown.
  2. Abbreviations: Arg, Glu, … – biosynthesis of L-amino acids.