Table 5 NADPH balance
From: A metabolite-centric view on flux distributions in genome-scale metabolic models
Producing fluxes | ||
|---|---|---|
Reaction/Enzyme | Pathway/Product | Ratio |
glucose 6-phosphate dehydrogenase | pentose phosphate pathway | 40.35% |
phosphogluconate dehydrogenase | pentose phosphate pathway | 40.35% |
isocitrate dehydrogenase | TCA cycle | 13.40% |
methylenetetrahydrofolate dehydrogenase | purines | 5.89% |
Consuming fluxes | ||
Reaction/Enzyme | Pathway/Product | Ratio |
glutamate dehydrogenase | Glu | 51.65% |
3-oxoacyl-[acyl-carrier-protein] reductase (11 reactions) | fatty acids | 13.41% |
ketol-acid reductoisomerase (2 reactions) | Val, Leu, Ile, coenzyme A | 6.95% |
aspartate semialdehyde dehydrogenase | Thr, Met, Lys, peptidoglycans | 6.43% |
sulfite reductase | sulfur metabolism | 4.57% |
homoserine dehydrogenase | Thr, Met | 4.21% |
shikimate dehydrogenase | shikimate pathway | 2.28% |
dihydrodipicolinate reductase | Lys, peptidoglycans | 2.22% |
thioredoxin reductase | conversions to other redox carriers | 2.14% |
N-acetyl-γ-glutamyl-phosphate reductase | Arg, polyamines | 2.01% |
glutamate 5-semialdehyde dehydrogenase | Pro | 1.32% |
pyrroline 5-carboxylate reductase | Pro | 1.32% |
glycerol 3-phosphate dehydrogenase | phospholipids | 1.03% |
UDP-N-acetylenolpyruvoylglucosamine reductase | peptidoglycans | 0.17% |
dihydrofolate reductase | folate metabolism | 0.16% |
dTDP-4-dehydrorhamnose reductase | lipopolysaccharides | 0.05% |