The reconstruction process for iTO977 and its comparison with Yeast 5. (A) Yeast genome-scale metabolic model pedigree. The iTO977 model (red) was reconstructed with the iIN800 model and the consensus network (blue) as starting points. The two starting point reconstructions were merged and further expanded by adding new pathways and reactions from databases and literature. (B) A comparison of the genes included in iTO977 and Yeast 5.