Figure 6

Simulation analyses of negative feedback loop from Ime2 to Ime1. A) Ime1 and Ime2 dynamics when varying d’ _ime1 , the maximum rate of Ime2-activated Ime1 degradation. Red curve: d’ _ime1  = 0 (deleting the feedback loop); cyan curve: d’ _ime1  = 0.1 (decreasing the feedback loop); blue curve: d’ _ime1  = 10 (increasing the feedback loop); green curve: d’ _ime1  = 1 (baseline value). B) Ime1 and Ime2 dynamics when varying c ₁ , the constant measuring half-maximum activation of Ime1 degradation by Ime2. Red curve: c ₁  = ∞ (deleting the feedback loop); cyan curve: c ₁  = 0.1 (decreasing the feedback loop); blue curve: c ₁  = 0.001 (increasing the feedback loop); green curve: c ₁  = 0.01 (baseline value). C) Ime1 and Ime2 dynamics when varying d’ _ime1 and c ₁ simultaneously. Red curve: d’ _ime1  = 0 and c ₁  = ∞ (deleting the feedback loop); cyan curve: d’ _ime1  = 0.1 and c ₁  = 0.1 (decreasing the feedback loop); blue curve: d’ _ime1  = 10 and c ₁  = 0.001 (increasing the feedback loop); green curve: d’ _ime1  = 1 and c ₁  = 0.01 (baseline value). The mathematical model of the feedback knockout is described in Additional file 2: Table S7.