Figure 7
Simulation analyses of positive feedback loop of Ime2. A) Ime1 and Ime2 dynamics when varying s’ ime2 , the maximum rate of auto-regulation-dependent Ime2 synthesis. Red curve: s’ ime2  = 0 (deleting the feedback loop); cyan curve: s’ ime2  = 0.3 (decreasing the feedback loop); blue curve: s’ ime2  = 30 (increasing the feedback loop); green curve: s’ ime2  = 3 (baseline value). B) Ime1 and Ime2 dynamics when varying c 2 , the constant measuring half- maximum activation of Ime2 synthesis through auto-regulation. Red curve: c 2  = ∞ (deleting the feedback loop); cyan curve: c 2  = 14 (decreasing the feedback loop); blue curve: c 2  = 0.14 (increasing the feedback loop); green curve: c 2  = 1.4 (baseline value). C) Ime1 and Ime2 dynamics when varying s’ ime2 and c 2 simultaneously. Red curve: s’ ime2  = 0 and c 2  = ∞ (deleting the feedback loop); cyan curve: s’ ime2  = 0.3 and c 2  = 14 (decreasing the feedback loop); blue curve: s’ ime2  = 30 and c 2  = 0.14 (increasing the feedback loop); green curve: s’ ime2  = 3 and c 2  = 1.4 (baseline value). The mathematical model of the feedback knockout is described in Additional file 2: Table S8.